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The elimination of organelles evolved to provide more space for oxygen-carrying hemoglobin and to maintain the biconcave shape of RBCs [32]

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For example, reduced EAAT2 activity leads to elevated extracellular glutamate concentrations [309, 310], which trigger excessive calcium influx into both neurons and astrocytes

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In our study, however, 13 C-labelling of lactate was not detectable in human, consistent with previous reports of low conversion of glucose into lactate under normal physiological conditions 11,56